What Bicycle Therapeutics Plc does.

We are a clinical-stage pharmaceutical company developing a novel class of medicines, which we refer to as Bicycle ® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained to form two loops which stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. Bicycle molecules are a unique therapeutic modality combining the pharmacology usually associated with a biologic with the manufacturing and pharmacokinetic, or PK, properties of a small molecule. The relatively large surface area presented by Bicycle molecules allows targets to be drugged that have historically been intractable to non-biological approaches. Bicycle molecules are excreted by the kidney rather than the liver and have shown no significant signs of immunogenicity to date, qualities which we believe explain the molecules’ favorable toxicological profile.

We have a novel and proprietary phage display screening platform which we use to identify Bicycle molecules in an efficient manner. The platform initially displays linear peptides on the surface of engineered bacteriophages, or phages, before “on-phage” cyclization with a range of small molecule scaffolds which can confer differentiated physicochemical and structural properties. Our platform encodes quintillions of potential Bicycle molecules which can be screened to identify molecules for optimization to potential product candidates. We have used this powerful screening technology to identify our current portfolio of candidates in oncology and intend to use it in conjunction with our collaborators to seek to develop additional future candidates across a range of other disease areas.

Revenue and profit, by fiscal year.

More on BCYC.

• Bicycle Therapeutics Plc summary
• Bicycle Therapeutics Plc financial statements
• Bicycle Therapeutics Plc key metrics
• Bicycle Therapeutics Plc health scores and style box
• Bicycle Therapeutics Plc earnings
• Bicycle Therapeutics Plc dividends
• Bicycle Therapeutics Plc valuation
• Bicycle Therapeutics Plc ownership and insiders
• Bicycle Therapeutics Plc peers

Figures from Bicycle Therapeutics Plc's filings with the U.S. SEC, standardised automatically; prices are end-of-day closes. Not financial advice.